Endocrine Abstracts

Introduction: Current treatment for SIADH related hyponatremia is unsatisfactory. We describe two cases of effective Tolvaptan use in SIADH related to disseminated cancer.Case 1: Fifty-three year old female with metastatic ovarian carcinoma, vomiting from partial intestinal obstruction, was referred with sodium 121 mmol and normal renal function. She was clinically dry and mildly confused. SIADH was confirmed but urine Na was <10 suggestive of hypovo...

Gums inflammation (gingivitis) if not treated on time and permitted to grow, ends into periodontitis in which alveolar bone that supports teeth is invaded and destroyed. Juvenile periodontitis is a genetic disorder and can occur without plaque and calculus. It is a disease of people below 30 years of age.Subjects and methods: This cross sectional study involved a total of 160 subjects including 80 chronic periodontitis patients and 80 healthy controls be...

Sarcoidosis is a very rare inflammatory disease and UK prevalence was 8% between 2008 to 2012 of which only 15 % developed neurosarcoidosis. Our patient is a 83 year old gentleman who presented with symptoms of lethargy, low blood pressure and confusion over 2 weeks . He had multiple comorbidities including heart failure, chronic kidney disease, permanent pacemaker, hypertension. His bloods showed normocytic anaemia and raised inflammatory markers, with eosinophilia and he was...

Background: Obesity, and metabolic syndrome (MS) are highly prevalent in Saudi Arabia, increasing the risk for type 2 diabetes (T2DM), and cardiovascular disease (CVD). Oligonol produced from lychee fruit polyphenols (LFP) has been reported to reduce visceral obesity, and ameliorate MS in Japanese subject.Aim: To investigate the effect of oligonol supplementation on MS risk factors in overweight and obese Saudi females.Subjects and...

Background: Fibroblast growth factor 19 (FGF19) is an enterokine derived from the ileum, and synthesized in response to release of bile acids following food ingestion. It was proposed to be an important regulator of the postprandial adaptive metabolic response. by stimulating glycogen and protein synthesis in the liver, and down regulating glucose production after a meal. There is limited research investigating the association between FG-19 and metabolic dysregulation in overw...

Objectives: The prevalence of type 2 diabetes mellitus (T2DM) is increasing rapidly with obesity being a major risk factor. Adipocytes, besides storing fat, release a number of adipokines. Our study explored the association of leptin and resistin released by adipocytes in the pathogenesis of T2DM in context of metabolic syndrome.Methods: This was a cross sectional study in which we measured plasma levels of insulin, leptin and resistin in 50 healthy non-...

Introduction: Prevalence of obesity is increasing globally and in Saudi Arabia in particular. Obesity is associated with increased risk of diabetes and cardiovascular diseases. Therefore, studies to control obesity and its effect on health are important. Chitosan has been recommended as a suitable functional supplement for controlling obesity; and consequently; its associated complications. However, results were inconclusive.Aim: To investigate the effec...

Background: People with diabetes account for 15–20% of total inpatients in Scottish hospitals. Provision of specialised diabetes care is integral in minimising length of stay and diabetes-related complications in such patients. Consequently, inpatient diabetes teams have been implemented throughout the UK as recommended by the Joint British Diabetes Societies.Methods: The amalgamation of several Glasgow hospitals into a single large teaching hospita...

Introduction: Hypercalcaemia during pregnancy poses a risk to both the mother and foetus and can present a complex management issue. Although hypercalcaemia from any cause can occur during pregnancy, primary hyperparathyroidism is the most common cause but other rarer cause such as familial hypocalciuric hypercalcaemia (FHH) should be ruled out. Although usually posing no risk to the mother, infants of mothers with the disease are at risk for neonatal hypocalcaemia, and seizur...

Introduction: It is rare for patients with morbid obesity to become pregnant without assisted reproductive support. Spontaneous conception of triplets and their successful delivery by caesarean section is hitherto unreported. We report the case of world’s heaviest mother to undergo caesarean section with good outcome for mother and the babies.Case history: A 24 year old lady was seen in the antenatal clinic at 11 weeks of pregnancy. She weighed 140 ...